Assessment of intravenous pbi-shRNA PDX1 nanoparticle (OFHIRNA-PDX1) in yucatan swine
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چکیده
منابع مشابه
Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels
The aim of this study was to characterize two monoclonal antibodies (F6A11 and F109-D12) generated against Pdx1 (pancreatic and duodenal homeobox-1), a homeodomain transcription factor, which is critical for pancreas formation as well as for normal pancreatic beta cell function. For production of monoclonal antibodies, we immunized Robertsonian POSF (RBF)mice with a GST-Pdx1 fusion protein cont...
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Marc Nicolino*, Kathryn C. Claiborn*, Valérie Senée , Anne Boland , Doris A. Stoffers , Cécile Julier 4,5 1 Hôpital Femme-Mère-Enfant, Division of Pediatric Endocrinology, Lyon University, Lyon, France 2 INSERM U870, CIC, Lyon, France. Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism and the Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Sc...
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Mice with 50% Pdx1, a homeobox gene critical for pancreatic development, had worsening glucose tolerance with age and reduced insulin release in response to glucose, KCl, and arginine from the perfused pancreas. Surprisingly, insulin secretion in perifusion or static incubation experiments in response to glucose and other secretagogues was similar in islets isolated from Pdx1(+/-) mice compared...
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RB is a key substrate of Cdks and an important regulator of the mammalian cell cycle. RB either represses E2Fs that promote cell proliferation or enhances the activity of cell-specific factors that promote differentiation, although the mechanism that facilitates this dual interaction is unclear. Here, we demonstrate that RB associates with and stabilizes pancreatic duodenal homeobox-1 (Pdx-1) t...
متن کاملDiabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice
Endocrine and exocrine pancreas tissues are both derived from the posterior foregut endoderm, however, the interdependence of these two cell types during their formation is not well understood. In this study, we generated mutant mice, in which the exocrine tissue is hypoplastic, in order to reveal a possible requirement for exocrine pancreas tissue in endocrine development and/or function. Sinc...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2013
ISSN: 0929-1903,1476-5500
DOI: 10.1038/cgt.2013.68